During the late 80s and early 90s, Venezuela was leading an interesting project to create educational software with entertainment elements for kids at schools. The organization in charge of such a project was called CENAMEC (Centro Nacional para el Mejoramiento de Ensenaza de la Ciencia / Center for the improvement of science teaching).
The above video displays few screenshots from a Spanish language tutor called DOCTORSE, all graphics were produced (painted) by Enzo Gianvittorio using a basic software called GRASP running on MS-DOS.
The software production department was integrated by a multidisciplinary team of professionals from different background and areas of expertise, among them were Programmers, Engineers, Instructional Designers, Teachers, Graphic Designers, Musicians, etc. I personally was in charge of a group of five graphic designers who were taking part on each one of the different productions done. Among the tiles produced were: MEMORIA, DOCTORSE, ACERTANDONOS AL PETROLEO, RULETA, EL AHORCADO, OSTEON, etc.. (see external reference)
This is a classical animation using hand made drawings, scanning them and digitally colored and sequenced using early versions of multimedia software called Macromedia Director.